SYNTHESIS, CHARACTERIZATION AND ANTITUBERCULOSIS ACTIVITY OF NOVEL SERIES OF 3[2-oxo-2H-chromen-3yl)amino]- 2 aryl 1,3 Thiazolidine-4-one.
- Department of Chemistry, Dr.Harisingh Gour Central University, Sagar (M.P.) 470003 India
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In the present investigation different derivatives of 3(2-aryl methylidene hydrazinyl) –2H-chromene-2-one on condensation with thioglycollic acid yield the corresponding 3[2-oxo-2H-chromen-3yl)amino]- 2 aryl 1,3 Thiazolidine-4-one (IV A1-D5).The newly synthesized heterocycles were characterized on the basis of their chemical properties and spectroscopic data. All newly synthesized compound were evaluated for their antimycobacterial activities against Mycobacterial tuberculosis H37Ra, 106 CFU/ml..Some of the compounds exhibited a significant antimycobacterial activity when compared with the drugs such as Rifampicin and streptomycin.
[Shweta Saxena, Ratnesh Das and Arti Saxena (2015); SYNTHESIS, CHARACTERIZATION AND ANTITUBERCULOSIS ACTIVITY OF NOVEL SERIES OF 3[2-oxo-2H-chromen-3yl)amino]- 2 aryl 1,3 Thiazolidine-4-one. Int. J. of Adv. Res. 3 (Jul). 1094-1103] (ISSN 2320-5407). www.journalijar.com
